Intermediate filament (IF) protein tetramers contain two DNA‐ and core‐histone‐binding motifs in rotational symmetry in one and the same structural entity. We propose that IF protein oligomers might displace histone octamers from nucleosomes in the process of transcription initiation and elongation, to deposit them transiently on their α‐helical coiled‐coil domains. We further propose that structurally related proteins of the karyoskeleton, constructed from an α‐helical domain capable of coiled‐coil formation and a basic DNA‐binding region adjacent to it, may be similarly involved (...) in nucleosome activation. These proteins would function as auxiliary factors that disrupt nucleosomal structure to permit transcription and other DNA‐dependent processes to proceed expiditiously. (shrink)

Unlike nonhuman primates, thousands of bird species have articulatory capabilities that equal or surpass those of humans, and they develop their vocalizations through vocal imitation in a way that is very similar to how human infants learn to speak. An understanding of how speech mechanisms have evolved is therefore unlikely to yield key insights into how the human brain is special.

Pickering & Garrod's (P&G's) integrated model of production and comprehension includes no explicit role for nonlinguistic cognitive processes. Yet, how domain-general cognitive functions contribute to language processing has become clearer with well-specified theories and supporting data. We therefore believe that their account can benefit by incorporating functions like working memory and cognitive control into a unified model of language processing.

The past two decades have seen an outpouring of work in legal theory that is self-consciously critical of aspects of American law and the institutions of the liberal state. In this lively volume, eminent scholars in philosophy, law, and political science respond to this recent scholarship by exploring what constitutes a "radical" critique of the law, examining such theories as critical legal studies, feminist theory and theories of "difference," and critical race theory. The authors consider whether the critiques advanced in (...) recent legal theory can truly be called radical and what form a radical critique of American law should take. Writing at the cutting edge of the critique of critical legal theory, they offer insights first on critical legal scholarship, then on feminist political and legal theory. A third group of contributions questions the radicalness of these approaches in light of their failure to challenge fundamental aspects of liberalism, while a final section focuses on current issues of legal reform through critical views on criminal punishment, including observations on rape and hate speech. Each major essay describes the underlying principles in the development of a radical legal theory and addresses unresolved questions relating to it, while accompanying commentaries present conflicting views. The resulting dialogue explores wide-ranging issues like equity, value relativism, adversarial and empathic legal advocacy, communitarianism and the social contract, impartiality and contingency, "natural" law, and corrective justice. A common thread for many of the articles is a focus on the social dimension of society and law, which finds the individualism of prevailing liberal theories too limiting. Radical Critiques of the Law is particularly unique in presenting critical and feminist approaches in one volume-along with skeptical commentary about just how radical some critiques really are. Proposing alternative critiques that embody considerably greater promise of being truly radical, it offers provocative reading for both philosophers and legal scholars by showing that many claims to radicalism are highly problematic at best. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:BOOK REVIEWS 113 phers); nevertheless, I feel that the book would have been more effective pedagogically had they devoted more attention to them than they have. As a specific recommendation, I would suggest several short introductions at strategic places in the text devoted to a brief resum~ of the historical setting in which the philosophers to be discussed found themselves. Once again I should emphasize that, despite the criticisms (...) I have made, I think the book to be an excellent piece of work, which should prove quite successful as an undergraduate text in the history of philosophy. OLIVER JOHNSON University of California, Riverside Plato's Theory of Knowledge. By Norman Gulley. (London: Methuen & Co. Ltd.; New York: Barnes & Noble Inc. Pp. viii ~ 203.) Mr. Gulley gives an account of the development of Plato's theory of knowledge. The impetus to this development he finds in an inconsistency that underlies the attempt to combine an a priori method of analysis with a theory of knowledge based on the doctrines of recollection and the archetype-copy relation of Forms and sensibles. Only in the last chapter, "Mathematical Knowledge," does he suggest a theory of the relation of a priori to empirical knowledge which he thinks might have satisfied Plato. The major part of the work, the first three chapters, concerns the conflicts and readjustments occasioned by the underlying inconsistency. I shall discuss these chapters in terms of a few central points. In chapter I, GuUey attempts to get at the basis of the theoretical difficulties. He points out that Plato first considers philosophic method as independent of the theory of Forms and the theory of recollection (pp. 40 f). In the Meno it is a method of analysis, which is a forerunner of the Phaedo's method of hypothesis, of which the dialectical method is a further development. It is an a priori method. But the theories, which are first hypotheses examined by the method (Phaedo), become later "presuppositions for the effective practice of the method," as, for example, in the Republic. In "recollection" there is an intimate connection between Forms and sensiblcs, but in knowledge there is complete separation. This is what Gulley considers to be the source of the major difficulties. Since I do not find these difficulties, I shall concentrate on their exposition. Gulley notes in the Phaedo two meanings of "giving an account": (1) in terms of a method of propositional analysis; (2) in terms of participation of sensibles in Forms. His explanation of the first offers no difficulties, but of the second there are serious problems. His explication of the second is as follows: To "give an account" is "to explain one's possession of a Form by showing that it is necessarily implied by that judgment of the 'deficiency' of sensible characters which arises as soon as they are recognized" (p. 40). His argument for this interpretation is as follows: "... if to know a Form brings with it the ability 'to give an account', and if to know a Form is to be reminded of it by the sensibles which resemble it (74 b-c), the 'giving of an account' must be explicable within the conception of 'knowledge' implied in the use of the term in 74 b-c" (p. 46). He assumes that Plato is at least consistent. Now in 74 b-c Simmias agrees with Socrates that we have knowledge of equality "in and by itself" and that such things as equal logs and stones "lead us to conceive" of it. Only "recollection," not the preexistent knowledge of Forms is in question here. Since it is assumed that knowledge implies the ability to give an account of what is known, then this instance of knowledge, which occurs in conjunction with perception, implies a similar ability. But one cannot infer from this that the discussion of equality as Plato has discussed it, which is a discussion of it as an example of recollection, is the same thing as the giving an account of equality itself, much less that it is "the only type of account possible" within the theory of Forms. That it is the only possible type is in fact contradicted by the assumption of pre... (shrink)

Primate vocal communication is very different from human language. Differences are most pronounced in call production. Differences in production have been overemphasized, however, and distracted attention from the information that primates acquire when they hear vocalizations. In perception and cognition, continuities with language are more apparent. We suggest that natural selection has favored nonhuman primates who, upon hearing vocalizations, form mental representations of other individuals, their relationships, and their motives. This social knowledge constitutes a discrete, combinatorial system that shares several (...) features with language. It is probably a general primate characteristic whose appearance pre-dates the evolution of spoken language in our hominid ancestors. The prior evolution of social cognition created individuals who were preadapted to develop language. Several features thought to be unique to language—like discrete combinatorics and the encoding of propositional information—were not introduced by language. They arose, instead, because understanding social life and predicting others’ behavior requires a particular style of thinking. (shrink)

This is the first of four papers to be published in Research Ethics Review in 2009 that address methodological issues of relevance to research ethics committees. These will be practical papers, intended to assist ethics committee members to determine whether a research method is both ethically justified and likely to lead to high quality research. This paper prepares the way for the series through a consideration of the relationship between research ethics and methodology.

In many countries the debate over the role that physicians may play in ending life has been limited to the judiciary and other law making institutions, professional medical organizations; and academics. Because of their multidisciplinary and diverse membership, ethics committees may be a particularly appropriate venue through which these discussions can be expanded to include a much larger community. In addition, ethics committees generally act in only advisory capacities because they do not actually make decisions, so they may provide a (...) forum for open discussions in ways that the court and the medical boards cannot. (shrink)

In three experiments we studied lay observers’ attributions of responsibility for an antisocial act (homicide). We systematically varied both the degree to which the action was coerced by external circumstances and the degree to which the actor endorsed and accepted ownership of the act, a psychological state that philosophers have termed ‘identification’. Our findings with respect to identification were highly consistent. The more an actor was identified with an action, the more likely observers were to assign responsibility to the actor, (...) even when the action was performed under constraints so powerful that no other behavioral option was available. Our findings indicate that social cognition involving assignment of responsibility for an action is a more complex process than previous research has indicated. It would appear that laypersons’ judgments of moral responsibility may, in some circumstances, accord with philosophical views in which freedom and determinism are regarded to be compatible. (shrink)

My goal in this paper is twofold: to provide an account of what makes properties morally relevant, and to indicate the role such properties have in our moral thinking.

Schizophrenia affects more than 1% of the world's population, causing great personal suffering and socioeconomic burden. These costs associated with schizophrenia necessitate inquiry into the causes and treatment of the illness but generate ethical challenges related to the specific nature and deficits of the illness itself. In this article, we present a systematic analysis of narrative data from 63 people living with the illness of schizophrenia collected through semistructured interviews about their attitudes, beliefs, and experiences related to psychiatric research. In (...) the comments of these individuals, half of whom had had prior personal experience in research protocols, we identified factors influencing openness toward research involvement as well as deterrents that appear to lessen interest in participation. Clear response pattern differences emerged between those with prior research experience and those without such experience. In the discussion, we explore these key findings and outline the implications for safeguards in mental illness research. (shrink)